Intrabodies targeting the Kaposi’s sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells
نویسندگان
چکیده
Sofia Corte-Real, Chris Collins, Frederico Aires da Silva, J. Pedro Simas, Carlos Barbas III, Yuan Chang, Patrick Moore and Joao Goncalves URIA-Centro de Patogénese Molecular, Faculty of Pharmacy, University of Lisbon, 1649-019 Lisbon, Portugal Molecular Virology Program, Hillman CancerRresearch Centre, University of Pittsburgh, Pittsburgh, PA 15213-1863 Department of Molecular Biology and Skaggs Institute for Chemical Biology,, The Scripps Research Institute, La Jolla, California 92037 Laboratório de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal e Instituto Gulbenkian de Ciência, Oeiras, Portugal
منابع مشابه
GENE THERAPY Intrabodies targeting the Kaposi sarcoma–associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells
Kaposi sarcoma–associated herpesvirus (KSHV) latency-associated nuclear antigen-1 (LANA1) is essential for the maintenance and segregation of viral episomes in KSHV latently infected B cells. We report development of intracellular, rabbitderived antibodies generated by phage display technology, which bind to Nterminal LANA1 epitopes and neutralize the chromosome-binding activity of LANA1. Altho...
متن کاملIntrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.
Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen-1 (LANA1) is essential for the maintenance and segregation of viral episomes in KSHV latently infected B cells. We report development of intracellular, rabbit-derived antibodies generated by phage display technology, which bind to N-terminal LANA1 epitopes and neutralize the chromosome-binding activity of LANA1. Alt...
متن کاملKaposi’s Sarcoma Herpesvirus Genome Persistence
Kaposi's sarcoma-associated herpesvirus (KSHV) has an etiologic role in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. These diseases are most common in immunocompromised individuals, especially those with AIDS. Similar to all herpesviruses, KSHV infection is lifelong. KSHV infection in tumor cells is primarily latent, with only a small subset of cells underg...
متن کاملModulation of Immune System by Kaposi’s Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies
Kaposi's sarcoma-associated herpesvirus (KSHV), a member of the herpesvirus family, has evolved to establish a long-term, latent infection of cells such that while they carry the viral genome gene expression is highly restricted. Latency is a state of cryptic viral infection associated with genomic persistence in their host and this hallmark of KSHV infection leads to several clinical-epidemiol...
متن کاملPathology of Kaposi’s Sarcoma-Associated Herpesvirus Infection
Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) is a human herpesvirus, classified as a gamma-herpesvirus. KSHV is detected in Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and some cases of multicentric Castleman's disease (MCD). Similar to other herpes viruses, there are two phases of infection, latent and lytic. In KSHV-associated malignancies such as KS and PEL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005